The study focused on the knowledge, perception and practice of the use of nose mask among students of Holy Family Nursing and Midwifery Training College, Berekum. A descriptive study design was used to collect in-depth information for the study. The sample population was obtained using a proportionate stratified sampling technique. A total of 100 students were sampled for the study. The data for the study was collected by administering the questionnaire to the participants. The study found that the majority of the respondents (54%) agreed that nose mask prevents the direct transfer of infectious pathogens. Majority of the respondents (85%) strongly agreed that incorrect usage of nose mask poses a health risk. Majority of the respondents (86%) agreed that face mask is effective in preventing spreading of droplets. Majority of the respondents (95%) strongly disagreed that one should remove his or her face mask when talking. The study recommended that all people who hold administrative positions in hospitals or schools should take the necessary measures to properly observe and implement the guidelines for wearing nose mask.The study concluded that the wearing of nose mask was high and the majority of the respondents perceived that face mask is effective in preventing spreading of droplets.